Searchable abstracts of presentations at key conferences in endocrinology

ea0022oc5.4 | Reproduction & Thyroid | ECE2010

One hormone, two functions: the chorionic gonadotropin in New World Monkeys

Adams Christian , Henke Alexander , Gromoll Jorg

Objective: The LH and chorionic gonadotropin (CG) are essential for reproduction and male sexual development. While LH induces tesosterone production, CG is essential for the establishment of pregnancy. In the New World Monkeys (NWM) the initial duplication of the ancestral LH-beta subunit (LHB) gene, which gave rise to the novel CG-beta subunit (CGB) gene, was followed by a genomic rearrangement event, leading to CGB expression in pituitary and placenta, whereas LHB became a ...